Methods Used for Dose-Aware Concentration Interpolation/Extrapolation

Bill Denney

Introduction

Interpolation and extrapolation with awareness of doses occurring before, at the same time of, or after the requested interpolation time point must account for many interactions. To ensure clarity in the interpolation/extrapolation methods and the decisions made by the algorithm, each potential choice is listed below with its accompanying calculation method. The code used to generate the table is the same as the code within the function.

Methods

The method list below is described and sorted in order of how many scenarios the method is applied to in the list.

For each of the summary tables below, the column headers are as follows:

• Event Before: The type of event before the time of the requested output may be one of the following
• Event At: The equivalent to “Event Before” but for the event occurring at the requested output time.
• Event After: The equivalent to “Event Before” but for the next event occurring after the requested output time.

Observed concentration

Copy the input concentration at the given time to the output.

Event Before	Event At	Event After
conc	conc	conc
conc	conc	conc_dose
conc	conc	conc_dose_iv_bolus_after
conc	conc	dose
conc	conc	dose_iv_bolus_after
conc	conc	none
conc	conc_dose	conc
conc	conc_dose	conc_dose
conc	conc_dose	conc_dose_iv_bolus_after
conc	conc_dose	dose
conc	conc_dose	dose_iv_bolus_after
conc	conc_dose	none
conc	conc_dose_iv_bolus_after	conc
conc	conc_dose_iv_bolus_after	conc_dose
conc	conc_dose_iv_bolus_after	dose
conc	conc_dose_iv_bolus_after	none
conc_dose	conc	conc
conc_dose	conc	conc_dose
conc_dose	conc	conc_dose_iv_bolus_after
conc_dose	conc	dose
conc_dose	conc	dose_iv_bolus_after
conc_dose	conc	none
conc_dose	conc_dose	conc
conc_dose	conc_dose	conc_dose
conc_dose	conc_dose	conc_dose_iv_bolus_after
conc_dose	conc_dose	dose
conc_dose	conc_dose	dose_iv_bolus_after
conc_dose	conc_dose	none
conc_dose	conc_dose_iv_bolus_after	conc
conc_dose	conc_dose_iv_bolus_after	conc_dose
conc_dose	conc_dose_iv_bolus_after	dose
conc_dose	conc_dose_iv_bolus_after	none
conc_dose_iv_bolus_after	conc	conc
conc_dose_iv_bolus_after	conc	conc_dose
conc_dose_iv_bolus_after	conc	conc_dose_iv_bolus_after
conc_dose_iv_bolus_after	conc	dose
conc_dose_iv_bolus_after	conc	dose_iv_bolus_after
conc_dose_iv_bolus_after	conc	none
conc_dose_iv_bolus_after	conc_dose	conc
conc_dose_iv_bolus_after	conc_dose	conc_dose
conc_dose_iv_bolus_after	conc_dose	conc_dose_iv_bolus_after
conc_dose_iv_bolus_after	conc_dose	dose
conc_dose_iv_bolus_after	conc_dose	dose_iv_bolus_after
conc_dose_iv_bolus_after	conc_dose	none
dose	conc	conc
dose	conc	conc_dose
dose	conc	conc_dose_iv_bolus_after
dose	conc	dose
dose	conc	dose_iv_bolus_after
dose	conc	none
dose	conc_dose	conc
dose	conc_dose	conc_dose
dose	conc_dose	conc_dose_iv_bolus_after
dose	conc_dose	dose
dose	conc_dose	dose_iv_bolus_after
dose	conc_dose	none
dose	conc_dose_iv_bolus_after	conc
dose	conc_dose_iv_bolus_after	conc_dose
dose	conc_dose_iv_bolus_after	dose
dose	conc_dose_iv_bolus_after	none
dose_iv_bolus_after	conc	conc
dose_iv_bolus_after	conc	conc_dose
dose_iv_bolus_after	conc	conc_dose_iv_bolus_after
dose_iv_bolus_after	conc	dose
dose_iv_bolus_after	conc	dose_iv_bolus_after
dose_iv_bolus_after	conc	none
dose_iv_bolus_after	conc_dose	conc
dose_iv_bolus_after	conc_dose	conc_dose
dose_iv_bolus_after	conc_dose	conc_dose_iv_bolus_after
dose_iv_bolus_after	conc_dose	dose
dose_iv_bolus_after	conc_dose	dose_iv_bolus_after
dose_iv_bolus_after	conc_dose	none
none	conc	conc
none	conc	conc_dose
none	conc	conc_dose_iv_bolus_after
none	conc	dose
none	conc	dose_iv_bolus_after
none	conc	none
none	conc_dose	conc
none	conc_dose	conc_dose
none	conc_dose	conc_dose_iv_bolus_after
none	conc_dose	dose
none	conc_dose	dose_iv_bolus_after
none	conc_dose	none
none	conc_dose_iv_bolus_after	conc
none	conc_dose_iv_bolus_after	conc_dose
none	conc_dose_iv_bolus_after	dose
none	conc_dose_iv_bolus_after	none

Impossible combinations

The event combination cannot exist.

Event Before	Event At	Event After
conc	conc_dose_iv_bolus_after	conc_dose_iv_bolus_after
conc	conc_dose_iv_bolus_after	dose_iv_bolus_after
conc	dose_iv_bolus_after	conc_dose_iv_bolus_after
conc	dose_iv_bolus_after	dose_iv_bolus_after
conc	output_only	conc_dose_iv_bolus_after
conc	output_only	dose_iv_bolus_after
conc_dose	conc_dose_iv_bolus_after	conc_dose_iv_bolus_after
conc_dose	conc_dose_iv_bolus_after	dose_iv_bolus_after
conc_dose	dose_iv_bolus_after	conc_dose_iv_bolus_after
conc_dose	dose_iv_bolus_after	dose_iv_bolus_after
conc_dose	output_only	conc_dose_iv_bolus_after
conc_dose	output_only	dose_iv_bolus_after
conc_dose_iv_bolus_after	conc_dose_iv_bolus_after	conc
conc_dose_iv_bolus_after	conc_dose_iv_bolus_after	conc_dose
conc_dose_iv_bolus_after	conc_dose_iv_bolus_after	conc_dose_iv_bolus_after
conc_dose_iv_bolus_after	conc_dose_iv_bolus_after	dose
conc_dose_iv_bolus_after	conc_dose_iv_bolus_after	dose_iv_bolus_after
conc_dose_iv_bolus_after	conc_dose_iv_bolus_after	none
conc_dose_iv_bolus_after	dose_iv_bolus_after	conc
conc_dose_iv_bolus_after	dose_iv_bolus_after	conc_dose
conc_dose_iv_bolus_after	dose_iv_bolus_after	conc_dose_iv_bolus_after
conc_dose_iv_bolus_after	dose_iv_bolus_after	dose
conc_dose_iv_bolus_after	dose_iv_bolus_after	dose_iv_bolus_after
conc_dose_iv_bolus_after	dose_iv_bolus_after	none
conc_dose_iv_bolus_after	output_only	conc_dose_iv_bolus_after
conc_dose_iv_bolus_after	output_only	dose_iv_bolus_after
dose	conc_dose_iv_bolus_after	conc_dose_iv_bolus_after
dose	conc_dose_iv_bolus_after	dose_iv_bolus_after
dose	dose_iv_bolus_after	conc_dose_iv_bolus_after
dose	dose_iv_bolus_after	dose_iv_bolus_after
dose	output_only	conc_dose_iv_bolus_after
dose	output_only	dose_iv_bolus_after
dose_iv_bolus_after	conc_dose_iv_bolus_after	conc
dose_iv_bolus_after	conc_dose_iv_bolus_after	conc_dose
dose_iv_bolus_after	conc_dose_iv_bolus_after	conc_dose_iv_bolus_after
dose_iv_bolus_after	conc_dose_iv_bolus_after	dose
dose_iv_bolus_after	conc_dose_iv_bolus_after	dose_iv_bolus_after
dose_iv_bolus_after	conc_dose_iv_bolus_after	none
dose_iv_bolus_after	dose_iv_bolus_after	conc
dose_iv_bolus_after	dose_iv_bolus_after	conc_dose
dose_iv_bolus_after	dose_iv_bolus_after	conc_dose_iv_bolus_after
dose_iv_bolus_after	dose_iv_bolus_after	dose
dose_iv_bolus_after	dose_iv_bolus_after	dose_iv_bolus_after
dose_iv_bolus_after	dose_iv_bolus_after	none
dose_iv_bolus_after	output_only	conc_dose_iv_bolus_after
dose_iv_bolus_after	output_only	dose_iv_bolus_after
none	conc_dose_iv_bolus_after	conc_dose_iv_bolus_after
none	conc_dose_iv_bolus_after	dose_iv_bolus_after
none	dose_iv_bolus_after	conc_dose_iv_bolus_after
none	dose_iv_bolus_after	dose_iv_bolus_after
none	output_only	conc_dose_iv_bolus_after
none	output_only	dose_iv_bolus_after

Doses with no concentrations between

Two doses with no concentrations between them, return NA.

Event Before	Event At	Event After
conc_dose	dose	conc
conc_dose	dose	conc_dose
conc_dose	dose	conc_dose_iv_bolus_after
conc_dose	dose	dose
conc_dose	dose	dose_iv_bolus_after
conc_dose	dose	none
conc_dose	output_only	conc_dose
conc_dose	output_only	dose
dose	dose	conc
dose	dose	conc_dose
dose	dose	conc_dose_iv_bolus_after
dose	dose	dose
dose	dose	dose_iv_bolus_after
dose	dose	none
dose	output_only	conc_dose
dose	output_only	dose

Extrapolation

Extrapolate from a concentration to a dose

Event Before	Event At	Event After
conc	dose	conc
conc	dose	conc_dose
conc	dose	conc_dose_iv_bolus_after
conc	dose	dose
conc	dose	dose_iv_bolus_after
conc	dose	none
conc	output_only	dose
conc	output_only	none
conc_dose_iv_bolus_after	dose	conc
conc_dose_iv_bolus_after	dose	conc_dose
conc_dose_iv_bolus_after	dose	conc_dose_iv_bolus_after
conc_dose_iv_bolus_after	dose	dose
conc_dose_iv_bolus_after	dose	dose_iv_bolus_after
conc_dose_iv_bolus_after	dose	none
conc_dose_iv_bolus_after	output_only	dose
conc_dose_iv_bolus_after	output_only	none

Immediately after an IV bolus without a concentration next

Cannot calculate C0 without a concentration after an IV bolus; return NA.

Event Before	Event At	Event After
conc	dose_iv_bolus_after	dose
conc	dose_iv_bolus_after	none
conc_dose	dose_iv_bolus_after	dose
conc_dose	dose_iv_bolus_after	none
dose	dose_iv_bolus_after	dose
dose	dose_iv_bolus_after	none
dose_iv_bolus_after	dose	conc
dose_iv_bolus_after	dose	conc_dose
dose_iv_bolus_after	dose	conc_dose_iv_bolus_after
dose_iv_bolus_after	dose	dose
dose_iv_bolus_after	dose	dose_iv_bolus_after
dose_iv_bolus_after	dose	none
none	dose_iv_bolus_after	dose
none	dose_iv_bolus_after	none

Before all events

Interpolation before any events is NA or zero (0) depending on the value of conc.origin. conc.origin defaults to zero which is the implicit assumption that a complete washout occurred and there is no endogenous source of the analyte.

Event Before	Event At	Event After
none	dose	conc
none	dose	conc_dose
none	dose	conc_dose_iv_bolus_after
none	dose	dose
none	dose	dose_iv_bolus_after
none	dose	none
none	output_only	conc
none	output_only	conc_dose
none	output_only	dose
none	output_only	none

Immediately after an IV bolus with a concentration next

Calculate C0 for the time immediately after an IV bolus. First, attempt using log slope back-extrapolation. If that fails, use the first concentration after the dose as C0.

Event Before	Event At	Event After
conc	dose_iv_bolus_after	conc
conc	dose_iv_bolus_after	conc_dose
conc_dose	dose_iv_bolus_after	conc
conc_dose	dose_iv_bolus_after	conc_dose
dose	dose_iv_bolus_after	conc
dose	dose_iv_bolus_after	conc_dose
none	dose_iv_bolus_after	conc
none	dose_iv_bolus_after	conc_dose

Interpolation

With concentrations before and after and not an IV bolus before, interpolate between observed concentrations.

Event Before	Event At	Event After
conc	output_only	conc
conc	output_only	conc_dose
conc_dose	output_only	conc
conc_dose_iv_bolus_after	output_only	conc
conc_dose_iv_bolus_after	output_only	conc_dose

After an IV bolus with a concentration next

First, calculate C0 using log slope back-extrapolation (falling back to the first post-dose concentration if that fails). Then, interpolate between C0 and the first post-dose concentration.

Event Before	Event At	Event After
dose_iv_bolus_after	output_only	conc
dose_iv_bolus_after	output_only	conc_dose

After an IV bolus without a concentration next

Between an IV bolus and anything other than a concentration, interpolation cannot occur. Return NA

Event Before	Event At	Event After
dose_iv_bolus_after	output_only	dose
dose_iv_bolus_after	output_only	none

Dose as the last event in the timeline and requesting a concentration after

Cannot estimate the concentration after a dose without concentrations after the dose, return NA.

Event Before	Event At	Event After
conc_dose	output_only	none
dose	output_only	none

Dose before, concentration after without a dose

If the concentration at the dose is estimable, interpolate. Otherwise, NA.

Event Before	Event At	Event After
dose	output_only	conc

Appendix: Complete Methods Table

Event Before	Event At	Event After	Method Used
conc	conc	conc	Observed concentration
conc	conc	conc_dose	Observed concentration
conc	conc	conc_dose_iv_bolus_after	Observed concentration
conc	conc	dose	Observed concentration
conc	conc	dose_iv_bolus_after	Observed concentration
conc	conc	none	Observed concentration
conc	conc_dose	conc	Observed concentration
conc	conc_dose	conc_dose	Observed concentration
conc	conc_dose	conc_dose_iv_bolus_after	Observed concentration
conc	conc_dose	dose	Observed concentration
conc	conc_dose	dose_iv_bolus_after	Observed concentration
conc	conc_dose	none	Observed concentration
conc	conc_dose_iv_bolus_after	conc	Observed concentration
conc	conc_dose_iv_bolus_after	conc_dose	Observed concentration
conc	conc_dose_iv_bolus_after	conc_dose_iv_bolus_after	Impossible combinations
conc	conc_dose_iv_bolus_after	dose	Observed concentration
conc	conc_dose_iv_bolus_after	dose_iv_bolus_after	Impossible combinations
conc	conc_dose_iv_bolus_after	none	Observed concentration
conc	dose	conc	Extrapolation
conc	dose	conc_dose	Extrapolation
conc	dose	conc_dose_iv_bolus_after	Extrapolation
conc	dose	dose	Extrapolation
conc	dose	dose_iv_bolus_after	Extrapolation
conc	dose	none	Extrapolation
conc	dose_iv_bolus_after	conc	Immediately after an IV bolus with a concentration next
conc	dose_iv_bolus_after	conc_dose	Immediately after an IV bolus with a concentration next
conc	dose_iv_bolus_after	conc_dose_iv_bolus_after	Impossible combinations
conc	dose_iv_bolus_after	dose	Immediately after an IV bolus without a concentration next
conc	dose_iv_bolus_after	dose_iv_bolus_after	Impossible combinations
conc	dose_iv_bolus_after	none	Immediately after an IV bolus without a concentration next
conc	output_only	conc	Interpolation
conc	output_only	conc_dose	Interpolation
conc	output_only	conc_dose_iv_bolus_after	Impossible combinations
conc	output_only	dose	Extrapolation
conc	output_only	dose_iv_bolus_after	Impossible combinations
conc	output_only	none	Extrapolation
conc_dose	conc	conc	Observed concentration
conc_dose	conc	conc_dose	Observed concentration
conc_dose	conc	conc_dose_iv_bolus_after	Observed concentration
conc_dose	conc	dose	Observed concentration
conc_dose	conc	dose_iv_bolus_after	Observed concentration
conc_dose	conc	none	Observed concentration
conc_dose	conc_dose	conc	Observed concentration
conc_dose	conc_dose	conc_dose	Observed concentration
conc_dose	conc_dose	conc_dose_iv_bolus_after	Observed concentration
conc_dose	conc_dose	dose	Observed concentration
conc_dose	conc_dose	dose_iv_bolus_after	Observed concentration
conc_dose	conc_dose	none	Observed concentration
conc_dose	conc_dose_iv_bolus_after	conc	Observed concentration
conc_dose	conc_dose_iv_bolus_after	conc_dose	Observed concentration
conc_dose	conc_dose_iv_bolus_after	conc_dose_iv_bolus_after	Impossible combinations
conc_dose	conc_dose_iv_bolus_after	dose	Observed concentration
conc_dose	conc_dose_iv_bolus_after	dose_iv_bolus_after	Impossible combinations
conc_dose	conc_dose_iv_bolus_after	none	Observed concentration
conc_dose	dose	conc	Doses with no concentrations between
conc_dose	dose	conc_dose	Doses with no concentrations between
conc_dose	dose	conc_dose_iv_bolus_after	Doses with no concentrations between
conc_dose	dose	dose	Doses with no concentrations between
conc_dose	dose	dose_iv_bolus_after	Doses with no concentrations between
conc_dose	dose	none	Doses with no concentrations between
conc_dose	dose_iv_bolus_after	conc	Immediately after an IV bolus with a concentration next
conc_dose	dose_iv_bolus_after	conc_dose	Immediately after an IV bolus with a concentration next
conc_dose	dose_iv_bolus_after	conc_dose_iv_bolus_after	Impossible combinations
conc_dose	dose_iv_bolus_after	dose	Immediately after an IV bolus without a concentration next
conc_dose	dose_iv_bolus_after	dose_iv_bolus_after	Impossible combinations
conc_dose	dose_iv_bolus_after	none	Immediately after an IV bolus without a concentration next
conc_dose	output_only	conc	Interpolation
conc_dose	output_only	conc_dose	Doses with no concentrations between
conc_dose	output_only	conc_dose_iv_bolus_after	Impossible combinations
conc_dose	output_only	dose	Doses with no concentrations between
conc_dose	output_only	dose_iv_bolus_after	Impossible combinations
conc_dose	output_only	none	Dose as the last event in the timeline and requesting a concentration after
conc_dose_iv_bolus_after	conc	conc	Observed concentration
conc_dose_iv_bolus_after	conc	conc_dose	Observed concentration
conc_dose_iv_bolus_after	conc	conc_dose_iv_bolus_after	Observed concentration
conc_dose_iv_bolus_after	conc	dose	Observed concentration
conc_dose_iv_bolus_after	conc	dose_iv_bolus_after	Observed concentration
conc_dose_iv_bolus_after	conc	none	Observed concentration
conc_dose_iv_bolus_after	conc_dose	conc	Observed concentration
conc_dose_iv_bolus_after	conc_dose	conc_dose	Observed concentration
conc_dose_iv_bolus_after	conc_dose	conc_dose_iv_bolus_after	Observed concentration
conc_dose_iv_bolus_after	conc_dose	dose	Observed concentration
conc_dose_iv_bolus_after	conc_dose	dose_iv_bolus_after	Observed concentration
conc_dose_iv_bolus_after	conc_dose	none	Observed concentration
conc_dose_iv_bolus_after	conc_dose_iv_bolus_after	conc	Impossible combinations
conc_dose_iv_bolus_after	conc_dose_iv_bolus_after	conc_dose	Impossible combinations
conc_dose_iv_bolus_after	conc_dose_iv_bolus_after	conc_dose_iv_bolus_after	Impossible combinations
conc_dose_iv_bolus_after	conc_dose_iv_bolus_after	dose	Impossible combinations
conc_dose_iv_bolus_after	conc_dose_iv_bolus_after	dose_iv_bolus_after	Impossible combinations
conc_dose_iv_bolus_after	conc_dose_iv_bolus_after	none	Impossible combinations
conc_dose_iv_bolus_after	dose	conc	Extrapolation
conc_dose_iv_bolus_after	dose	conc_dose	Extrapolation
conc_dose_iv_bolus_after	dose	conc_dose_iv_bolus_after	Extrapolation
conc_dose_iv_bolus_after	dose	dose	Extrapolation
conc_dose_iv_bolus_after	dose	dose_iv_bolus_after	Extrapolation
conc_dose_iv_bolus_after	dose	none	Extrapolation
conc_dose_iv_bolus_after	dose_iv_bolus_after	conc	Impossible combinations
conc_dose_iv_bolus_after	dose_iv_bolus_after	conc_dose	Impossible combinations
conc_dose_iv_bolus_after	dose_iv_bolus_after	conc_dose_iv_bolus_after	Impossible combinations
conc_dose_iv_bolus_after	dose_iv_bolus_after	dose	Impossible combinations
conc_dose_iv_bolus_after	dose_iv_bolus_after	dose_iv_bolus_after	Impossible combinations
conc_dose_iv_bolus_after	dose_iv_bolus_after	none	Impossible combinations
conc_dose_iv_bolus_after	output_only	conc	Interpolation
conc_dose_iv_bolus_after	output_only	conc_dose	Interpolation
conc_dose_iv_bolus_after	output_only	conc_dose_iv_bolus_after	Impossible combinations
conc_dose_iv_bolus_after	output_only	dose	Extrapolation
conc_dose_iv_bolus_after	output_only	dose_iv_bolus_after	Impossible combinations
conc_dose_iv_bolus_after	output_only	none	Extrapolation
dose	conc	conc	Observed concentration
dose	conc	conc_dose	Observed concentration
dose	conc	conc_dose_iv_bolus_after	Observed concentration
dose	conc	dose	Observed concentration
dose	conc	dose_iv_bolus_after	Observed concentration
dose	conc	none	Observed concentration
dose	conc_dose	conc	Observed concentration
dose	conc_dose	conc_dose	Observed concentration
dose	conc_dose	conc_dose_iv_bolus_after	Observed concentration
dose	conc_dose	dose	Observed concentration
dose	conc_dose	dose_iv_bolus_after	Observed concentration
dose	conc_dose	none	Observed concentration
dose	conc_dose_iv_bolus_after	conc	Observed concentration
dose	conc_dose_iv_bolus_after	conc_dose	Observed concentration
dose	conc_dose_iv_bolus_after	conc_dose_iv_bolus_after	Impossible combinations
dose	conc_dose_iv_bolus_after	dose	Observed concentration
dose	conc_dose_iv_bolus_after	dose_iv_bolus_after	Impossible combinations
dose	conc_dose_iv_bolus_after	none	Observed concentration
dose	dose	conc	Doses with no concentrations between
dose	dose	conc_dose	Doses with no concentrations between
dose	dose	conc_dose_iv_bolus_after	Doses with no concentrations between
dose	dose	dose	Doses with no concentrations between
dose	dose	dose_iv_bolus_after	Doses with no concentrations between
dose	dose	none	Doses with no concentrations between
dose	dose_iv_bolus_after	conc	Immediately after an IV bolus with a concentration next
dose	dose_iv_bolus_after	conc_dose	Immediately after an IV bolus with a concentration next
dose	dose_iv_bolus_after	conc_dose_iv_bolus_after	Impossible combinations
dose	dose_iv_bolus_after	dose	Immediately after an IV bolus without a concentration next
dose	dose_iv_bolus_after	dose_iv_bolus_after	Impossible combinations
dose	dose_iv_bolus_after	none	Immediately after an IV bolus without a concentration next
dose	output_only	conc	Dose before, concentration after without a dose
dose	output_only	conc_dose	Doses with no concentrations between
dose	output_only	conc_dose_iv_bolus_after	Impossible combinations
dose	output_only	dose	Doses with no concentrations between
dose	output_only	dose_iv_bolus_after	Impossible combinations
dose	output_only	none	Dose as the last event in the timeline and requesting a concentration after
dose_iv_bolus_after	conc	conc	Observed concentration
dose_iv_bolus_after	conc	conc_dose	Observed concentration
dose_iv_bolus_after	conc	conc_dose_iv_bolus_after	Observed concentration
dose_iv_bolus_after	conc	dose	Observed concentration
dose_iv_bolus_after	conc	dose_iv_bolus_after	Observed concentration
dose_iv_bolus_after	conc	none	Observed concentration
dose_iv_bolus_after	conc_dose	conc	Observed concentration
dose_iv_bolus_after	conc_dose	conc_dose	Observed concentration
dose_iv_bolus_after	conc_dose	conc_dose_iv_bolus_after	Observed concentration
dose_iv_bolus_after	conc_dose	dose	Observed concentration
dose_iv_bolus_after	conc_dose	dose_iv_bolus_after	Observed concentration
dose_iv_bolus_after	conc_dose	none	Observed concentration
dose_iv_bolus_after	conc_dose_iv_bolus_after	conc	Impossible combinations
dose_iv_bolus_after	conc_dose_iv_bolus_after	conc_dose	Impossible combinations
dose_iv_bolus_after	conc_dose_iv_bolus_after	conc_dose_iv_bolus_after	Impossible combinations
dose_iv_bolus_after	conc_dose_iv_bolus_after	dose	Impossible combinations
dose_iv_bolus_after	conc_dose_iv_bolus_after	dose_iv_bolus_after	Impossible combinations
dose_iv_bolus_after	conc_dose_iv_bolus_after	none	Impossible combinations
dose_iv_bolus_after	dose	conc	Immediately after an IV bolus without a concentration next
dose_iv_bolus_after	dose	conc_dose	Immediately after an IV bolus without a concentration next
dose_iv_bolus_after	dose	conc_dose_iv_bolus_after	Immediately after an IV bolus without a concentration next
dose_iv_bolus_after	dose	dose	Immediately after an IV bolus without a concentration next
dose_iv_bolus_after	dose	dose_iv_bolus_after	Immediately after an IV bolus without a concentration next
dose_iv_bolus_after	dose	none	Immediately after an IV bolus without a concentration next
dose_iv_bolus_after	dose_iv_bolus_after	conc	Impossible combinations
dose_iv_bolus_after	dose_iv_bolus_after	conc_dose	Impossible combinations
dose_iv_bolus_after	dose_iv_bolus_after	conc_dose_iv_bolus_after	Impossible combinations
dose_iv_bolus_after	dose_iv_bolus_after	dose	Impossible combinations
dose_iv_bolus_after	dose_iv_bolus_after	dose_iv_bolus_after	Impossible combinations
dose_iv_bolus_after	dose_iv_bolus_after	none	Impossible combinations
dose_iv_bolus_after	output_only	conc	After an IV bolus with a concentration next
dose_iv_bolus_after	output_only	conc_dose	After an IV bolus with a concentration next
dose_iv_bolus_after	output_only	conc_dose_iv_bolus_after	Impossible combinations
dose_iv_bolus_after	output_only	dose	After an IV bolus without a concentration next
dose_iv_bolus_after	output_only	dose_iv_bolus_after	Impossible combinations
dose_iv_bolus_after	output_only	none	After an IV bolus without a concentration next
none	conc	conc	Observed concentration
none	conc	conc_dose	Observed concentration
none	conc	conc_dose_iv_bolus_after	Observed concentration
none	conc	dose	Observed concentration
none	conc	dose_iv_bolus_after	Observed concentration
none	conc	none	Observed concentration
none	conc_dose	conc	Observed concentration
none	conc_dose	conc_dose	Observed concentration
none	conc_dose	conc_dose_iv_bolus_after	Observed concentration
none	conc_dose	dose	Observed concentration
none	conc_dose	dose_iv_bolus_after	Observed concentration
none	conc_dose	none	Observed concentration
none	conc_dose_iv_bolus_after	conc	Observed concentration
none	conc_dose_iv_bolus_after	conc_dose	Observed concentration
none	conc_dose_iv_bolus_after	conc_dose_iv_bolus_after	Impossible combinations
none	conc_dose_iv_bolus_after	dose	Observed concentration
none	conc_dose_iv_bolus_after	dose_iv_bolus_after	Impossible combinations
none	conc_dose_iv_bolus_after	none	Observed concentration
none	dose	conc	Before all events
none	dose	conc_dose	Before all events
none	dose	conc_dose_iv_bolus_after	Before all events
none	dose	dose	Before all events
none	dose	dose_iv_bolus_after	Before all events
none	dose	none	Before all events
none	dose_iv_bolus_after	conc	Immediately after an IV bolus with a concentration next
none	dose_iv_bolus_after	conc_dose	Immediately after an IV bolus with a concentration next
none	dose_iv_bolus_after	conc_dose_iv_bolus_after	Impossible combinations
none	dose_iv_bolus_after	dose	Immediately after an IV bolus without a concentration next
none	dose_iv_bolus_after	dose_iv_bolus_after	Impossible combinations
none	dose_iv_bolus_after	none	Immediately after an IV bolus without a concentration next
none	output_only	conc	Before all events
none	output_only	conc_dose	Before all events
none	output_only	conc_dose_iv_bolus_after	Impossible combinations
none	output_only	dose	Before all events
none	output_only	dose_iv_bolus_after	Impossible combinations
none	output_only	none	Before all events