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Exclude NCA parameters based on examining the parameter set.

Source: R/exclude_nca.R
exclude_nca.Rd

Exclude NCA parameters based on examining the parameter set.

Usage

exclude_nca_span.ratio(min.span.ratio)

exclude_nca_max.aucinf.pext(max.aucinf.pext)

exclude_nca_min.hl.r.squared(min.hl.r.squared)

Arguments

min.span.ratio

The minimum acceptable span ratio (uses PKNCA.options("min.span.ratio") if not provided).

max.aucinf.pext

The maximum acceptable percent AUC extrapolation (uses PKNCA.options("max.aucinf.pext") if not provided).

min.hl.r.squared

The minimum acceptable r-squared value for half-life (uses PKNCA.options("min.hl.r.squared") if not provided).

Functions

  • exclude_nca_span.ratio(): Exclude based on span.ratio

  • exclude_nca_max.aucinf.pext(): Exclude based on AUC percent extrapolated (both observed and predicted)

  • exclude_nca_min.hl.r.squared(): Exclude based on half-life r-squared

See also

Other Result exclusions: exclude()

Examples

my_conc <- PKNCAconc(data.frame(conc=1.1^(3:0),
                                time=0:3,
                                subject=1),
                     conc~time|subject)
my_data <- PKNCAdata(my_conc,
                     intervals=data.frame(start=0, end=Inf,
                                          aucinf.obs=TRUE,
                                          aucpext.obs=TRUE))
my_result <- pk.nca(my_data)
#> No dose information provided, calculations requiring dose will return NA.
my_result_excluded <- exclude(my_result,
                              FUN=exclude_nca_max.aucinf.pext())
as.data.frame(my_result_excluded)
#> # A tibble: 14 × 6
#>    subject start   end PPTESTCD            PPORRES exclude                      
#>      <dbl> <dbl> <dbl> <chr>                 <dbl> <chr>                        
#>  1       1     0   Inf auclast              3.47   NA                           
#>  2       1     0   Inf tmax                 0      NA                           
#>  3       1     0   Inf tlast                3      NA                           
#>  4       1     0   Inf clast.obs            1      NA                           
#>  5       1     0   Inf lambda.z             0.0953 NA                           
#>  6       1     0   Inf r.squared            1      NA                           
#>  7       1     0   Inf adj.r.squared        1      NA                           
#>  8       1     0   Inf lambda.z.time.first  1      NA                           
#>  9       1     0   Inf lambda.z.n.points    3      NA                           
#> 10       1     0   Inf clast.pred           1      NA                           
#> 11       1     0   Inf half.life            7.27   NA                           
#> 12       1     0   Inf span.ratio           0.275  NA                           
#> 13       1     0   Inf aucinf.obs          14.0    AUC percent extrapolated > 20
#> 14       1     0   Inf aucpext.obs         75.1    AUC percent extrapolated > 20