Create a PKNCAconc object

## Usage

```
PKNCAconc(data, ...)
# Default S3 method
PKNCAconc(data, ...)
# S3 method for class 'tbl_df'
PKNCAconc(data, ...)
# S3 method for class 'data.frame'
PKNCAconc(
data,
formula,
subject,
time.nominal,
exclude = NULL,
duration,
volume,
exclude_half.life,
include_half.life,
sparse = FALSE,
...
)
```

## Arguments

- data
A data frame with concentration (or amount for urine/feces), time, and the groups defined in

`formula`

.- ...
Ignored.

- formula
The formula defining the

`concentration~time|groups`

or`amount~time|groups`

for urine/feces (In the remainder of the documentation, "concentration" will be used to describe concentration or amount.) One special aspect of the`groups`

part of the formula is that the last group is typically assumed to be the`subject`

; see the documentation for the`subject`

argument for exceptions to this assumption.- subject
The column indicating the subject number. If not provided, this defaults to the beginning of the inner groups: For example with

`concentration~time|Study+Subject/Analyte`

, the inner groups start with the first grouping variable before a`/`

,`Subject`

. If there is only one grouping variable, it is assumed to be the subject (e.g.`concentration~time|Subject`

), and if there are multiple grouping variables without a`/`

, subject is assumed to be the last one. For single-subject data, it is assigned as`NULL`

.- time.nominal
(optional) The name of the nominal time column (if the main time variable is actual time. The

`time.nominal`

is not used during calculations; it is available to assist with data summary and checking.- exclude
(optional) The name of a column with concentrations to exclude from calculations and summarization. If given, the column should have values of

`NA`

or`""`

for concentrations to include and non-empty text for concentrations to exclude.- duration
(optional) The duration of collection as is typically used for concentration measurements in urine or feces.

- volume
(optional) The volume (or mass) of collection as is typically used for urine or feces measurements.

- exclude_half.life, include_half.life
A character scalar for the column name in the dataset of the points to exclude from the half-life calculation (still using normal curve-stripping selection rules for the other points) or to include for the half-life (using specifically those points and bypassing automatic curve-stripping point selection). See the "Half-Life Calculation" vignette for more details on the use of these arguments.

- sparse
Are the concentration-time data sparse PK (commonly used in small nonclinical species or with terminal or difficult sampling) or dense PK (commonly used in clinical studies or larger nonclinical species)?

## See also

Other PKNCA objects:
`PKNCAdata()`

,
`PKNCAdose()`

,
`PKNCAresults()`