Calculate the mean residence time (MRT) for multiple-dose data with nonlinear kinetics.

Calculate the mean residence time (MRT) for multiple-dose data with nonlinear kinetics.

Usage

pk.calc.mrt.md(auctau, aumctau, aucinf, tau)

Arguments

auctau

the AUC from time 0 to the end of the dosing interval (tau).

aumctau

the AUMC from time 0 to the end of the dosing interval (tau).

aucinf

the AUC from time 0 to infinity (typically using single-dose data)

tau

The dosing interval

Details

mrt.md is aumctau/auctau + tau*(aucinf-auctau)/auctau and should only be used for multiple dosing with equal intervals between doses.

Note that if aucinf == auctau (as would be the assumption with linear kinetics), the equation becomes the same as the single-dose MRT.

See also

pk.calc.mrt()