Compute pharmacokinetic (PK) noncompartmental analysis (NCA) parameters.
Details
PKNCA has been cross-validated with both Phoenix WinNonlin(R) and Pumas (click here for the cross-validation article)
A common workflow would load data from a file or database into a data.frame then run the following code.
Author
Maintainer: Bill Denney wdenney@humanpredictions.com (ORCID)
Authors:
Clare Buckeridge clare.buckeridge@pfizer.com
Other contributors:
Sridhar Duvvuri [contributor]
Examples
if (FALSE) { # \dontrun{
# Load concentration-time data into a data.frame called d.conc
# with columns named "conc", "time", and "subject".
my.conc <- PKNCAconc(d.conc, conc~time|subject)
# Load dose-time data into a data.frame called d.dose
# with columns named "dose", "time", and "subject".
my.dose <- PKNCAdose(d.dose, dose~time|subject)
# Combine the concentration-time and dose-time data into an object
# ready for calculations.
my.data <- PKNCAdata(my.conc, my.dose)
# Perform the calculations
my.results <- pk.nca(my.data)
# Look at summary results
summary(my.results)
# Look at a listing of results
as.data.frame(my.results)
} # }