Pharmacokinetics of an CPI 975 (an experimental drug) reported in Table II of Nedelman 1995

Observed data set of concentration-time data for an experimental compound. These data use sparse PK sampling with a "batch" design where each animal has more than one sample but not the full profile.

Usage

Nedelman_1995_conc

Nedelman_1995_dose

Nedelman_1995_demog

Format

Nedelman_1995_conc is a data frame describing concentration by time with the following variables:

ID: Subject identifier
TIME: Time (in hours)
TIMEU: Units for time, "hr"
CONC: Plasma concentration of the experimental compound (in ug/mL)
CONCU: Units for plasma concentration, "ug/mL"

Nedelman_1995_dose is a data frame describing dosing with the following variables:

ID: Subject identifier
DOSE: Dose (in mg/kg)
DOSEU: Units for nominal dose, "mg/kg"
TIME: Time for the dose (in hours, always 0)
TIMEU: Units for time, "hr"
ROUTE: Route of administration, "oral"

Nedelman_1995_demog is a data frame describing demographics with the following variables:

ID: Subject identifier
SEX: Animal sex
SPECIES: Species of the animal (always "rat")

An object of class data.frame with 60 rows and 5 columns.

An object of class data.frame with 60 rows and 6 columns.

An object of class data.frame with 60 rows and 3 columns.

References

Nedelman JR, Gibiansky E, Lau DT. Applying Bailer’s method for AUC confidence intervals to sparse sampling. Pharm Res. 1995;12(1):124-128. doi:10.1023/a:1016255124336