Pharmacokinetics of an experimental compound reported in Table 4 of Holder 1999

Observed data set of concentration-time data for an experimental compound. These data use sparse PK sampling with a "batch" design where each animal has more than one sample but not the full profile.

Usage

Holder_1999_conc

Holder_1999_dose

Holder_1999_demog

Format

Holder_1999_conc is a data frame describing concentration by time with the following variables:

ID: Subject identifier
TIME: Time (in hours)
TIMEU: Units for time, "hr"
CONC: Plasma concentration of the experimental compound (in ug/mL)
CONCU: Units for plasma concentration, "ug/mL"

Holder_1999_dose is a data frame describing dosing with the following variables:

ID: Subject identifier
DOSE: Dose (in mg/kg)
DOSEU: Units for nominal dose, "mg/kg"
TIME: Time for start of dose (in minutes)
TIMEU: Units for time, "minutes"
ROUTE: Route of administration, "intravenous bolus"

Holder_1999_demog is a data frame describing demographics with the following variables:

ID: Subject identifier
SEX: Animal sex (always "Female")
SPECIES: Species of the animal (always "rat")
GROUP: Arbitrary group number of the animal within the dose level

An object of class data.frame with 108 rows and 5 columns.

An object of class data.frame with 54 rows and 6 columns.

An object of class data.frame with 54 rows and 4 columns.

References

Holder DJ, Hsuan F, Dixit R, Soper K. A method for estimating and testing area under the curve in serial sacrifice, batch, and complete data designs. J Biopharm Stat. 1999;9(3):451-464. doi:10.1081/BIP-100101187